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FCRL3 promotes IL-10 expression in B cells through the SHP-1 and p38 MAPK signalling pathways.
This study further found that FCRL3 and IL-10 expression was downregulated in MS patients, but the expression of these proteins was higher in the remission phase than that in the acute phase. The C allele of rs7528684 was associated with MS, and the CC genotype could lead to the upregulation of FCRL3 expression and the increase in IL-10 secretion. Further in vitro experiments with B cells found that LPS promoted FCRL3 expression in a dose- and time-dependent manner, thereby promoting IL-10 secretion. LPS regulated SHP-1 expression and p38 MAPK pathway activation through FCRL3, and FCRL3 upregulated the SHP-1 expression and...
Source: Cell Biology International - May 5, 2020 Category: Cytology Authors: Cui X, Liu CM, Liu QB Tags: Cell Biol Int Source Type: research