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PSPH induces cell autophagy and promotes cell proliferation and invasion in the hepatocellular carcinoma cell line Huh7 via the AMPK/mTOR/ULK1 signaling pathway.
In conclusion, PSPH could induce autophagy, promote proliferation and invasion, and inhibit apoptosis in HCC cell via the AMPK/mTOR/ULK1 signaling pathway. This article is protected by copyright. All rights reserved. PMID: 33079432 [PubMed - as supplied by publisher]
Source: Cell Biology International - October 20, 2020 Category: Cytology Authors: Zhang J, Wang E, Zhang L, Zhou B Tags: Cell Biol Int Source Type: research

NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL-6 induced JAK2/STAT3 pathway activation.
This article is protected by copyright. All rights reserved. PMID: 32584509 [PubMed - as supplied by publisher]
Source: Cell Biology International - June 24, 2020 Category: Cytology Authors: Kang JH, Li MJ, Luan PP, Jiang DK, Chen YW, Xu X, Yu Q, Xu YW, Su Q, Peng WH, Jian WX Tags: Cell Biol Int Source Type: research

Calpains are required for invasive and metastatic potentials of human HCC cells.
Abstract Calpains are a conserved family of calcium-dependent cysteine proteinases involved in various cellular functions. Two ubiquitous isoforms, µ- and m-calpain, are key members of the calpain family that play essential roles in regulating cell migration and invasion. However, it remains unclear whether they are involved in the progression of hepatocellular carcinoma (HCC). Here, we investigated the functions of µ- and m-calpain in the invasive and metastatic processes of human hepatoma cells. Our results indicated that the expression levels of calpains were elevated in HCC cells compared with those in norma...
Source: Cell Biology International - June 7, 2013 Category: Cytology Authors: Chen B, Tang J, Guo YS, Li Y, Chen ZN, Jiang JL Tags: Cell Biol Int Source Type: research

SiRNA-targeted carboxypeptidase D inhibits hepatocellular carcinoma growth.
Abstract Carboxypeptidase D (CPD), a membrane-bound metallocarboxypeptidase that functions as a docking receptor for duck hepatitis B virus, is frequently overexpressed in human cancers. We have explored its expression pattern, clinical significance, and biological function of CPD in hepatocellular carcinoma (HCC). CPD expression was markedly elevated in HCCs relative to adjacent non-tumor liver tissues, as determined by quantitative real-time polymerase chain reaction and Western blot analysis. Immunohistochemistry showed that 164 of 400 (41%) HCCs had high expression of CPD. CPD overexpression was significantly ...
Source: Cell Biology International - April 16, 2013 Category: Cytology Authors: Jin T, Fu J, Feng XJ, Wang SM, Huang X, Zhu MH, Zhang SH Tags: Cell Biol Int Source Type: research