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Source: AJP: Cell Physiology
Cancer: Acute Leukemia
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Acute myotube protein synthesis regulation by IL-6-related cytokines
IL-6 and leukemia inhibitory factor (LIF), members of the IL-6 family of cytokines, play recognized paradoxical roles in skeletal muscle mass regulation, being associated with both growth and atrophy. Overload or muscle contractions can induce a transient increase in muscle IL-6 and LIF expression, which has a regulatory role in muscle hypertrophy. However, the cellular mechanisms involved in this regulation have not been completely identified. The induction of mammalian target of rapamycin complex 1 (mTORC1)-dependent myofiber protein synthesis is an established regulator of muscle hypertrophy, but the involvement of the ...
Source: AJP: Cell Physiology - November 1, 2017 Category: Cytology Authors: Gao, S., Durstine, J. L., Koh, H.-J., Carver, W. E., Frizzell, N., Carson, J. A. Tags: RESEARCH ARTICLE Source Type: research
