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Abstract A67: TFF (Trefoil Factor Family) is a novel tumor suppressor and can be the therapeutic target for pancreatic cancer
Conclusion: TFF1 and TFF2 act as tumor suppressor in pancreatic carcinogenesis in a different manner, and they can be a novel therapeutic target for PDAC.Citation Format: Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo, Masato Nagino.{Authors}. TFF (Trefoil Factor Family) is a novel tumor suppressor and can be the therapeutic target for pancreatic cancer. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2016 May 12-15; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(24 Suppl):Abstract nr A67.
Source: Cancer Research - December 13, 2016 Category: Cancer & Oncology Authors: Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo, Masato Nagino Tags: Early Detection Source Type: research

Abstract 883: Angiopoietin-like protein 2, a driver of cancer cell metastasis, is a novel serum biomarker for the diagnosis and prognosis in patients with gastric cancer
Background: Gastric carcinogenesis is regarded as a multistep process with an intestinal metaplasia-dysplasia-carcinoma sequence, which is initiated by Helicobacter pylori infection that causes a chronic active inflammation in the gastric mucosa. Angiopoietin-like protein 2 (ANGPTL2) is known to act as a causative mediator of chronic inflammation and inflammatory carcinogenesis. However, the biological role and clinical significance of ANGPTL2 expression remains poorly understood in human cancer. We investigated the functional role of ANGPTL2 and evaluated the clinical significance of its expression in both primary tumor a...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Toiyama, Y., Kitajima, T., Shimura, T., Imaoka, H., Kondo, S., Ide, S., Okigami, M., Yasuda, H., Saigusa, S., Ohi, M., Tanaka, K., Inoue, Y., Mhori, Y., Goel, A., Kusunoki, M. Tags: Clinical Research (Excluding Clinical Trials) Source Type: research

Abstract 1143: Induction of epithelial-mesenchymal transition (EMT) in human gastric cancer cell lines induced by Tip{alpha} of H. pylori mediated through surface nucleolin
Conclusions: This is the first report that Tipα is a new inducer of EMT in human gastric cancer cells, and that EMT was induced through the binding of Tipα to surface nucleolin. Citation Format: Hirota Fujiki, Tatsuro Watanabe, Atsushi Takahashi, Kaori Suzuki, Miki Kurusu-Kanno, Kensei Yamaguchi, Masami Suganuma. Induction of epithelial-mesenchymal transition (EMT) in human gastric cancer cell lines induced by Tipα of H. pylori mediated through surface nucleolin. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Fujiki, H., Watanabe, T., Takahashi, A., Suzuki, K., Kurusu-Kanno, M., Yamaguchi, K., Suganuma, M. Tags: Tumor Biology Source Type: research