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Effect of NR5A2 inhibition on pancreatic cancer stem cell (CSC) properties and epithelial ‐mesenchymal transition (EMT) markers
This study aims to demonstrate expression and potential role of NR5A2 in pancreatic cancer. NR5A2 expression was quantified in resected pancreatic ductal adenocarcinomas and the normal adjacent tissues of 134 patients by immunohistochemistry. The intensity and extent of NR5A2 staining was quantified and analyzed in association with overall survival (OS). The impact of NR5A2 knockdown on pancreatic cancer stem cell (CSC) properties and epithelial‐mesenchymal transition (EMT) markers was examined in cancer cells using RT‐PCR and Western Blot. NR5A2 was overexpressed in pancreatic tumors, the IHC‐staining H score (mean�...
Source: Molecular Carcinogenesis - December 19, 2016 Category: Molecular Biology Authors: Zhaofan Luo, Yanan Li, Zuo Mingxin, Chang Liu, Dong Yan, Huamin Wang, Donghui Li Tags: Research Article Source Type: research

Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial‐to‐mesenchymal transition (EMT) in bladder cancer
Activation of the sonic hedgehog (Shh) signaling pathway controls tumorigenesis in a variety of cancers. Here, we show a role for Shh signaling in the promotion of epithelial‐to‐mesenchymal transition (EMT), tumorigenicity, and stemness in the bladder cancer. EMT induction was assessed by the decreased expression of E‐cadherin and ZO‐1 and increased expression of N‐cadherin. The induced EMT was associated with increased cell motility, invasiveness, and clonogenicity. These progression relevant behaviors were attenuated by treatment with Hh inhibitors cyclopamine and GDC‐0449, and after knockdown by Shh‐siRNA,...
Source: Molecular Carcinogenesis - March 1, 2015 Category: Molecular Biology Authors: S.S. Islam, R.B. Mokhtari, A.S. Noman, M. Uddin, M.Z. Rahman, M.A. Azadi, A. Zlotta, T. van der Kwast, H. Yeger, W.A. Farhat Tags: Research Article Source Type: research