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p0071 interacts with E ‐cadherin in the cytoplasm so as to promote the invasion and metastasis of non‐small cell lung cancer
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - September 12, 2017 Category: Molecular Biology Authors: Huanyu Zhao, Di Zhang, Lianhe Yang, Enhua Wang Tags: RESEARCH ARTICLE Source Type: research

Lasp2 enhances tumor invasion via facilitating phosphorylation of FAK and predicts poor overall survival of non ‐small cell lung cancer patients
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - July 1, 2017 Category: Molecular Biology Authors: Xiupeng Zhang, Lin Cai, Haijing Zhou, Yang Liu, Chuifeng Fan, Liang Wang, Ailin Li, Yuan Miao, Qingchang Li, Xueshan Qiu, Enhua Wang Tags: RESEARCH ARTICLE Source Type: research

Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer
This study aimed at increasing the knowledge on the involvement of adhesion molecules in lung cancer progression by studying the regulation and role of NFASC in non‐small cell lung cancer (NSCLC). Here, copy number variations in the NFASC gene were analyzed in tumor and non‐tumorous lung tissues of 204 NSCLC patients. Frequent gene amplifications (OR = 4.50, 95%CI: 2.27‐8.92, P ≤ 0.001) and increased expression of NFASC (P = 0.034) were identified in tumors of NSCLC patients. Furthermore, molecular mechanisms of NFASC in lung cancer progression were evaluated by investigating the effects of NFASC silenc...
Source: Molecular Carcinogenesis - May 2, 2017 Category: Molecular Biology Authors: Johanna Samulin Erdem, Yke Jildouw Arnoldussen, Vidar Skaug, Aage Haugen, Shanbeh Zienolddiny Tags: RESEARCH ARTICLE Source Type: research

Copy number variation, increased gene expression and molecular mechanisms of Neurofascin in lung cancer
This study aimed at increasing the knowledge on the involvement of adhesion molecules in lung cancer progression by studying the regulation and role of NFASC in non‐small cell lung cancer (NSCLC). Here, copy number variations in the NFASC gene were analyzed in tumor and non‐tumorous lung tissues of 204 NSCLC patients. Frequent gene amplifications (OR = 4.50, 95% CI: 2.27‐8.92, P ≤ 0.001) and increased expression of NFASC (P = 0.034) were identified in tumors of NSCLC patients. Furthermore, molecular mechanisms of NFASC in lung cancer progression were evaluated by investigating the effects of NFASC silencing...
Source: Molecular Carcinogenesis - April 18, 2017 Category: Molecular Biology Authors: Johanna Samulin Erdem, Yke Jildouw Arnoldussen, Vidar Skaug, Aage Haugen, Shanbeh Zienolddiny Tags: RESEARCH ARTICLE Source Type: research

Kctd20 promotes the development of non ‐small cell lung cancer through activating Fak/AKT pathway and predicts poor overall survival of patients
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - April 11, 2017 Category: Molecular Biology Authors: Xiupeng Zhang, Haijing Zhou, Lin Cai, Chuifeng Fan, Yang Liu, Liang Wang, Qingchang Li, Yuan Miao Tags: RESEARCH ARTICLE Source Type: research

Src mediates extracellular signal‐regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non‐small cell lung cancer cell lines
Aberrant Na+/K+‐ATPases (NKA) expression is closely related to the incidence and development of cancer, making NKA targeted cancer therapy more intriguing. Cardiac glycosides (CGs) belong to NKA inhibitors and possess potent anti‐cancer properties in many cancers. Our previous work demonstrates that CGs family member digoxin or ouabain induces autophagic cell death in human non‐small cell lung cancer (NSCLC) cell lines through regulation of both mammalian target of rapamycin and extracellular signal‐regulated kinase 1/2 (ERK1/2) pathway. However, what acts as an upstream regulator of ERK1/2 activation during autoph...
Source: Molecular Carcinogenesis - March 1, 2014 Category: Molecular Biology Authors: Yan Wang, Yuechen Zhan, Rong Xu, Rongguang Shao, Jiandong Jiang, Zhen Wang Tags: Research Article Source Type: research