• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The impact of transcription factor Fli1 deficiency on the regulation of angiogenesis
Abstract The insufficiency of Friend leukaemia virus integration 1 (Fli1), a member of the Ets family transcription factors, is implicated in the pathogenesis of vasculopathy associated with systemic sclerosis (SSc). Fli1 deficiency accelerates early steps of angiogenesis, including detachment of pre‐existing pericytes and extracellular matrix degradation by endothelial proteinases, but the impact of Fli1 deficiency on the other steps of angiogenesis has not been investigated. Therefore, we evaluated the effect of Fli1 deficiency on migration, proliferation, cell survival and tube formation of human dermal microvascular ...
Source: Experimental Dermatology - July 10, 2017 Category: Dermatology Authors: Tetsuo Toyama, Yoshihide Asano, Takuya Miyagawa, Kouki Nakamura, Megumi Hirabayashi, Takashi Yamashita, Ryosuke Saigusa, Shunsuke Miura, Yohei Ichimura, Takehiro Takahashi, Takashi Taniguchi, Ayumi Yoshizaki, Shinichi Sato Tags: ORIGINAL ARTICLE Source Type: research

The impact of transcriptional factor Fli1 deficiency on the regulation of angiogenesis
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - March 31, 2017 Category: Dermatology Authors: Tetsuo Toyama, Yoshihide Asano, Takuya Miyagawa, Kouki Nakamura, Megumi Hirabayashi, Takashi Yamashita, Ryosuke Saigusa, Shunsuke Miura, Yohei Ichimura, Takehiro Takahashi, Takashi Taniguchi, Ayumi Yoshizaki, Shinichi Sato Tags: Regular Article Source Type: research

Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - August 29, 2016 Category: Dermatology Authors: Heba Dosoki, Agatha Stegemann, Muna Taha, Hans Schnittler, Thomas A. Luger, Katrin Schr öder, Jörg H. W. Distler, Claus Kerkhoff, Markus Böhm Tags: Regular Article Source Type: research

Long non‐coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization
Abstract Long non‐coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried to evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether lncRNAs controls collagen expression in dermal fibroblasts. lncRNA expression was determined by real‐time PCR and in situ hybridization. Protein and mRNA levels of collagen were analysed using immunoblotting and real‐time PCR. We found TSIX, one of the lncRNAs, was overexpressed in SSc dermal fibroblasts both in vivo and in vitro, which was inhibited by the transfection of transforming growth factor (TGF)...
Source: Experimental Dermatology - January 12, 2016 Category: Dermatology Authors: Zhongzhi Wang, Masatoshi Jinnin, Kayo Nakamura, Miho Harada, Hideo Kudo, Wakana Nakayama, Kuniko Inoue, Taiji Nakashima, Noritoshi Honda, Satoshi Fukushima, Hironobu Ihn Tags: Original Article Source Type: research

Long non‐coding RNA TSIX is up‐regulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - November 14, 2015 Category: Dermatology Authors: Zhongzhi Wang, Masatoshi Jinnin, Kayo Nakamura, Miho Harada, Hideo Kudo, Wakana Nakayama, Kuniko Inoue, Taiji Nakashima, Noritoshi Honda, Satoshi Fukushima, Hironobu Ihn Tags: Regular Article Source Type: research

Global DNA hypomethylation and hypoxia‐induced expression of the ten eleven translocation (TET) family, TET1, in scleroderma fibroblasts
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - May 25, 2015 Category: Dermatology Authors: Mai Hattori, Yoko Yokoyama, Tomoyasu Hattori, Sei‐ichiro Motegi, Hiroo Amano, Izuho Hatada, Osamu Ishikawa Tags: Regular Article Source Type: research