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Abstract C54: High caveolin-1 expression in a cohort of African American women with triple-negative breast cancer
In this study, gene expression profiling, using the Almac BC DSA Research Tool, was performed on archived FFPE samples, obtained from CA and AA women diagnosed with early stage (Node 0) TNBC. Unsupervised hierarchical clustering revealed a pattern of differential gene expression in the AA cohort compared to CA. Using the TNBC type: A Subtyping Tool for TNBC, we found a distinct distribution pattern of TNBC molecular subtypes in the AA cohort, which was very different than the CA cohort; Basal-like (14%), Immunomodulatory (43%) and Mesenchymal (43%). Gene expression analyses, comparing the AA and CA cohort (fold change >...
Source: Cancer Epidemiology Biomarkers and Prevention - April 14, 2016 Category: Cancer & Oncology Authors: Getz, J. E., Teoh, D. B., Nasser, S., Legendre, C. R., Tembe, W., Yellapantula, V., Ahearn, M. E., Gomez, C. R., Jorda, M., Wong, S. M., Pegram, M. D., Carpten, J. D., Baumbach-Reardon, L. L. Tags: Breast Cancer: Poster Presentations - Proffered Abstracts Source Type: research

Abstract B02: miR-1207-3p as a potential prostate cancer biomarker in Black males
In conclusion, we have discovered a novel miR-1207-3p-dependent FNDC1/FN1/AR molecular pathway that regulates proliferation of PCA cells derived from Black males. Consequently, miR-1207-3p may be a biomarker in PCA with potential clinical applications in Black males.Citation Format: Dibash Kumar Das, Adeodat Ilboudo, Olorunseun O. Ogunwobi. miR-1207-3p as a potential prostate cancer biomarker in Black males. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Ep...
Source: Cancer Epidemiology Biomarkers and Prevention - April 14, 2016 Category: Cancer & Oncology Authors: Das, D. K., Ilboudo, A., Ogunwobi, O. O. Tags: Biomarkers in Cancer Surveillance and Screening: Poster Presentations - Proffered Abstracts Source Type: research

Abstract B03: PVT1 exon 9 is a potential non-invasive biomarker that regulates apoptosis and the cell cycle in aggressive prostate cancer in black males
Prostate cancer (PCA) is the most common non-skin cancer and the second leading cause of cancer-related death for men in the U.S. Black males have a higher incidence of PCA, compared to White males. In fact, Black race is a confirmed, non-modifiable risk factor for PCA with a 2.5 fold greater risk of lethal PCA compared to Caucasian males. Discovery of effective early detection strategies are necessary to address the profound health disparity. The chromosomal region 8q24 is associated with aggressive PCA in Black men and variants of this region have been identified to interact with the PVT1 non-protein coding gene in PCA. ...
Source: Cancer Epidemiology Biomarkers and Prevention - April 14, 2016 Category: Cancer & Oncology Authors: Ilboudo, A., Das, D., Ogunwobi, O. O. Tags: Biomarkers in Cancer Surveillance and Screening: Poster Presentations - Proffered Abstracts Source Type: research

Abstract B24: Regulation of DARC isoforms among ancestry groups and associations with aggressive breast cancer subtypes
Biological mechanisms that drive disparate incidences of aggressive breast cancer in women of African descent are still largely unknown. Despite the fact that White women are more often diagnosed with breast cancer, African-American women have more severe cases and more often die from their breast cancer. Certain clues surrounding the tumor behavior and aggressive nature of cancers in African Americans point to physiological contexts, perhaps even the immunological microenvironment of the cancer sites. We hypothesize that higher mortality rates, coupled with lower incidence of breast cancer in this population, compared to ...
Source: Cancer Epidemiology Biomarkers and Prevention - April 14, 2016 Category: Cancer & Oncology Authors: Vollum, K., Hutchins, R., Brown, A. M., Perez, C., Davis, M. B. Tags: Cancer Genetics/Gene Expression: Poster Presentations - Proffered Abstracts Source Type: research

Abstract A74: Differential Wnt signaling in African American and Caucasian women with triple-negative breast cancer
In the U.S., breast cancer (BC) incidences among African American (AA) and Caucasian (CA) women are similar, however, AA have a significantly higher mortality rate (20%). In addition, AA women often present with tumors at a younger age, with a higher grade/later stage, and are more likely to be diagnosed with the highly aggressive triple-negative breast cancer (TNBC) subtype. Although multiple factors may contribute to the observed health disparities in TNBC, it is essential that we identify the molecular characteristics and underlying biological differences between CA and AA TNBC. We initially conducted a gene expression ...
Source: Cancer Epidemiology Biomarkers and Prevention - September 30, 2015 Category: Cancer & Oncology Authors: Getz, J. E., Teoh, D. B., Nasser, S., Waibhav, T., Christophe, L. R., Yellapantula, V., Ahearn, M. E., Gomez, C. R., Jorda, M., Pegram, M. D., Carpten, J. D., Baumbach, L. L. Tags: Cancer Genetics/Gene Expression: Poster Presentations - Proffered Abstracts Source Type: research

Abstract A83: Lentiviral shRNA-mediated knockdown of eosinophilic Galectin-10/Charcot-Leyden crystals: A novel approach to cancer immunotherapy
Conclusion: The creation of galectin-10 knockdown eosinophils provides a useful model for investigating eosinophilic galectin-10's ability to modulate T cell access and homing to tumors, and a putative role, similar to Treg galectin-10, in regulating tumoral T lymphocytic proliferation can certainly be envisioned. The consideration of galectin-10 knockdown eosinophils as a singular approach to cancer immunotherapy, or in combination with other anti-cancer therapies such as adoptive T cell therapies, or therapeutic cancer vaccines, is intriguing.Note: This abstract was not presented at the conference.Citation Format: Christ...
Source: Cancer Epidemiology Biomarkers and Prevention - September 30, 2015 Category: Cancer & Oncology Authors: Clarke, C. A., Lee, C. M., Laniyan, I., Furbert-Harris, P. Tags: Other Topics in Cell, Molecular, and Tumor Biology: Poster Presentations - Proffered Abstracts Source Type: research

Abstract C64: Iroquois homeobox gene 3 is temporally regulated in response to vascular endothelial growth factor and modulates endothelial cell migration
Conclusion: Our results provide compelling evidence that the homeobox gene irx3 regulates EC migration, and is directly regulated by TFs known to govern transcriptional signaling during angiogenesis.Citation Format: Kisha Scarlett, Pattabiraman Vaishnavi, Leonard Anderson. Iroquois homeobox gene 3 is temporally regulated in response to vascular endothelial growth factor and modulates endothelial cell migration. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstr...
Source: Cancer Epidemiology Biomarkers and Prevention - November 13, 2014 Category: Cancer & Oncology Authors: Scarlett, K., Vaishnavi, P., Anderson, L. Tags: Angiogenesis and Invasion: Poster Presentations - Proffered Abstracts Source Type: research

Abstract C20: Comparative proteomics analysis of ethnically stratified prostate cancer cells reveal potential markers of disparities
Conclusions: We demonstrate the differential expression of specific classes of proteins in prostate cancer cell lines with different ethnic and tumorigenic phenotypes. Some of these proteins may play a role in the progression, aggression and metastasis of PCa. These findings are currently being validated using disease stratified tissue microarrays to determine the expression patterns of these proteins in PCa patients. We are currently focusing on uncovering the potential mechanisms responsible for progression and aggression of PCa that are modulated by these proteins. These studies may provide novel avenues for the develop...
Source: Cancer Epidemiology Biomarkers and Prevention - November 13, 2014 Category: Cancer & Oncology Authors: Burch, T. C., Nyalwidhe, J. O. Tags: Other Topics in Biomarkers: Poster Presentations - Proffered Abstracts Source Type: research

Abstract C42: Quantitative high-throughput efficacy profiling of hedgehog/GLI pathway antagonists in inflammatory breast cancer
Conclusion: Several agents showed efficacy in in vitro IBC cancer models demonstrating that GLI inhibitors may be a valid therapeutic approach for targeting GLI-dependent IBC cancers.Funded in part by DOD/CDMRP IDEA W81XWH-13-1-0141(BC121850) (KP Williams)[1] W.F. Anderson, C. Schairer, B.E. Chen, K.W. Hance, P.H. Levine, Epidemiology of inflammatory breast cancer (IBC). Breast disease 22 (2006) 9-23.[2] W.A. Woodward, M. Cristofanilli, Inflammatory breast cancer. Seminars in Radiation Oncology 19 (2009) 256-265.[3] K.A. Hirko, A.S. Soliman, M. Banerjee, J. Ruterbusch, J.B. Harford, R.M. Chamberlain, J.J. Graff, S.D. Meraj...
Source: Cancer Epidemiology Biomarkers and Prevention - November 13, 2014 Category: Cancer & Oncology Authors: Oladapo, H., Ingram, S., Stefanowicz, A., Devi, G., Williams, K. Tags: Proteomics, Chemogenomics, and Chemoinformatics: Poster Presentations - Proffered Abstracts Source Type: research

Abstract C56: The role of BetaB2-crystallin in progression of colorectal and breast cancers in African Americans
Conclusions: Our data suggest that CRYBB2 inhibits apoptosis, activates EMT process and AKT phosphorylation by which it contributes the aggressiveness of CRC and BC. It may serve as a promising biomarker for identifying CRC and BC patients at high risk for metastases. It may also be useful as a therapeutic target to inhibit the growth and metastasis of CRC and BC. These studies are supported by NIH/NCI funds (R21-CA171251 and U54- CA 118948).Citation Format: Harvey L. Bumpers, Venkat Katkoori, Dongquan Chen, Upender Manne. The role of BetaB2-crystallin in progression of colorectal and breast cancers in African Americans. [...
Source: Cancer Epidemiology Biomarkers and Prevention - November 13, 2014 Category: Cancer & Oncology Authors: Bumpers, H. L., Katkoori, V., Chen, D., Manne, U. Tags: Tumor Promotion and Progression: Poster Presentations - Proffered Abstracts Source Type: research