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Source: Molecular Human Reproduction
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Spindlin 1 is essential for metaphase II stage maintenance and chromosomal stability in porcine oocytes
This study is based on <span style="font-style:italic;">in vitro</span> investigations with abnormal expression levels of Spin1. This may or may not accurately reflect the situation <span style="font-style:italic;">in vivo</span>.<div class="boxTitle">Wider implications of the findings</div>Spin1 is essential to maintain MII arrest, but a high level of Spin1 induces DNA damage in oocytes and embryos. Thus, a system to accurately regulate Spin1 expression operates in porcine MII-stage oocytes and embryos.<div class="boxTitle">Study funding and competing interest(s)</div>This r...
Source: Molecular Human Reproduction - March 6, 2017 Category: Molecular Biology Source Type: research