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Abstract 1848: PPAR{gamma} function is attenuated by full length androgen receptor and the AR-V7 variant in human prostate cancer cells
The peroxisome proliferator activated receptor gamma (PPARγ) is a ligand-activated transcription factor that regulates in vitro and in vivo growth of castration-resistant human prostate cancer (PCa) cells. However, the factors that control expression of PPARγ within human PCa have not been characterized. We have previously shown that the androgen dihydrotestosterone decreases PPARγ levels and transcriptional activity in human PCa cells. Dihydrotestosterone serves as a high affinity ligand for the 110 kD form of the androgen receptor (AR-FL). Recent studies have shown the development of castration-resistant forms of pros...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Olokpa, E., Stewart, L. V. Tags: Endocrinology Source Type: research