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A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes
AbstractSTUDY QUESTIONDoes A20 regulate mediators involved in the terminal processes of human labour in primary myometrial and amnion cells?SUMMARY ANSWERA20 is a nuclear factor-kappa B (NF- κB) responsive gene that acts as a negative regulator of NF-κB-induced expression of pro-labour mediators.WHAT IS KNOWN ALREADYInflammation is commonly implicated in spontaneous preterm birth and the processes involved in rupture of foetal membranes and uterine contractions. In myometrium and foetal membranes, the pro-inflammatory transcription factor NF- κB regulates the transcription of pro-labour mediators in response to inflamma...
Source: Molecular Human Reproduction - August 9, 2017 Category: Molecular Biology Source Type: research

Inhibition of PIM1 kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro
AbstractSTUDY QUESTIONDoes proviral integration site for Moloney murine leukaemic virus (PIM)1 kinase play a role in regulating the inflammatory processes of human labour and delivery?SUMMARY ANSWERPIM1 kinase plays a critical role in foetal membranes in regulating pro-inflammatory and pro-labour mediators.WHAT IS KNOWN ALREADYInfection and inflammation have strong causal links to preterm delivery by stimulating pro-inflammatory cytokines and collagen degrading enzymes, which can lead to rupture of membranes. PIM1 has been shown to have a role in immune regulation and inflammation in non-gestational tissues; however, its r...
Source: Molecular Human Reproduction - March 28, 2017 Category: Molecular Biology Source Type: research

Copper metabolism domain-containing 1 represses the mediators involved in the terminal effector pathways of human labour and delivery
STUDY HYPOTHESIS Does Copper Metabolism MURR1 Domain 1 (COMMD1) play a role in regulating the mediators involved in the terminal processes of human labour and delivery? STUDY FINDING COMMD1 plays a critical role in the termination of nuclear factor-B (NF-B) activity and the control of pro-inflammatory and pro-labour mediators. WHAT IS KNOWN ALREADY Inflammation and infection are the biggest aetiological factors associated with preterm birth. NF-B drives the transcription of pro-inflammatory mediators involved in the terminal effector pathways of human labour and delivery. In non-gestational tissues, COMMD1 is a negative ...
Source: Molecular Human Reproduction - March 31, 2016 Category: Molecular Biology Authors: Lappas, M. Tags: Articles Source Type: research

Abstract 1848: PPAR{gamma} function is attenuated by full length androgen receptor and the AR-V7 variant in human prostate cancer cells
The peroxisome proliferator activated receptor gamma (PPARγ) is a ligand-activated transcription factor that regulates in vitro and in vivo growth of castration-resistant human prostate cancer (PCa) cells. However, the factors that control expression of PPARγ within human PCa have not been characterized. We have previously shown that the androgen dihydrotestosterone decreases PPARγ levels and transcriptional activity in human PCa cells. Dihydrotestosterone serves as a high affinity ligand for the 110 kD form of the androgen receptor (AR-FL). Recent studies have shown the development of castration-resistant forms of pros...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Olokpa, E., Stewart, L. V. Tags: Endocrinology Source Type: research

ER{beta}-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1
STUDY QUESTION What are the in vitro effects of estrogen receptor β (ERβ) activation on the function of endothelial cells (ECs) from different vascular beds: human endometrial ECs (HEECs; endometrium), uterine myometrial microvascular ECs (UtMVECs; myometrium) and human umbilical vein ECs (HUVECs)? SUMMARY ANSWER Studies conducted in vitro demonstrate that the ERβ agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile (DPN) has EC type-specific effects on patterns of gene expression and network formation. Identification of a key role for the transcription factor Sp1 in ERβ-dependent signaling in uterine ECs o...
Source: Human Reproduction - August 21, 2013 Category: Reproduction Medicine Authors: Greaves, E., Collins, F., Critchley, H. O. D., Saunders, P. T. K. Tags: Reproductive biology Source Type: research