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Source: Connective Tissue Research
Drug: Nicotine
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SOCS3 participates in cholinergic pathway regulation of synovitis in rheumatoid arthritis.
This study investigated the effect of SOCS on cholinergic pathway regulation of synovitis in the fibroblast-like synoviocytes (FLSs) of RA and CIA mice. The effects of nicotine on SOCS1 and SOCS3 protein expression in FLSs were assayed by western blotting before and after transfection with a small interfering RNA oligonucleotide (SOCS3-siRNA or control-siRNA). Interleukin-6 was measured by enzyme-linked immunosorbent assay of SOCS3-siRNA and control-siRNA transfected FLS culture supernatants. Histopathological evaluation and immunohistochemical staining of SOCS3 were performed in joint tissue sections of control, CIA model...
Source: Connective Tissue Research - September 17, 2017 Category: Research Tags: Connect Tissue Res Source Type: research
