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Melatonin induces progesterone production in human granulosa-lutein cells through upregulation of StAR expression.
Abstract Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in ovarian steroidogenesis and progesterone (P4) synthesis. Melatonin and its receptors are expressed in human granulosa cells, and have been shown to influence basal P4 production. However, previous studies addressing the regulation of StAR expression by melatonin and its impact on P4 secretion yielded contradictory results. Here, we demonstrate that melatonin upregulates StAR expression in primary cultures of human granulosa-lutein (hGL) cells obtained from women undergoing in vitro fertilization (IVF). Using pharmacological i...
Source: Aging - October 15, 2019 Category: Biomedical Science Authors: Fang L, Li Y, Wang S, Yu Y, Li Y, Guo Y, Yan Y, Sun YP Tags: Aging (Albany NY) Source Type: research