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Source: Cellular and Molecular Biology
Drug: Melatonin
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Total 5 results found since Jan 2013.
Melatonin Sensitizes OVCAR-3 Cells to Cisplatin through Suppression of PI3K/Akt Pathway
This study examined the effect of melatonin on oxidative stress, expression of pro-apoptotic protein, anti-apoptotic proteins, and the activity of the PI3K/Akt signaling pathway in the human ovarian cancer cell line (OVCAR3). OVCAR3 cells were treated with cisplatin, melatonin, cisplatin + melatonin, and siRNA Akt. Reactive oxygen species levels were assessed. The expression of the proteins was determined by Western blot. Melatonin administration significantly increased intracellular ROS generation, the cleavage of caspase 3 and decreased phosphorylation of Akt. Combination therapy of cisplatin and melatonin increases apop...
Source: Cellular and Molecular Biology - August 21, 2022 Category: Molecular Biology Authors: Sahar Baghal-Sadriforoush Morteza Bagheri Isa Abdi Rad Fattah Sotoodehnejadnematalahi Source Type: research
