Filtered By:
Condition: Atrial Fibrillation
Drug: Melatonin
This page shows you your search results in order of date.
Order by Relevance | Date
Total 2 results found since Jan 2013.
Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP)
In this study, Ang II was used to induce AF, and AF inducibility and duration were documented telemetrically. Ang II-infused mice had a higher AF incidence, which was associated with atrial fibrosis, inflammation, and oxidative stress. Melatonin partially inhibited these effects, and enforced expression of siRNA-ATRAP in atria counteracted the beneficial role of melatonin. Specifically, melatonin inhibited expression of Ang II-induced proteasome and immunoproteasome subunits β2, β2i, β5, and β5i as well as their corresponding trypsin-like and chymotrypsin-like activities and blocked ATRAP degradation. In turn, this inh...
Source: Biochemical Pharmacology - June 16, 2022 Category: Drugs & Pharmacology Authors: Xin Xie Ting-Ting Shen Hai-Lian Bi Zhuo-Lin Su Zi-Qi Liao Ying Zhang Lei Shi Yun-Long Xia Source Type: research
