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Condition: Parkinson's Disease
Drug: Melatonin
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Total 3 results found since Jan 2013.
Melatonin attenuates MPP < sup > + < /sup > -induced apoptosis via heat shock protein in a Parkinson's disease model
Biochem Biophys Res Commun. 2022 Jul 1;621:59-66. doi: 10.1016/j.bbrc.2022.06.099. Online ahead of print.ABSTRACTHeat shock proteins (HSPs) play an essential role as molecular chaperones to prevent abnormal protein aggregation and misfolding. Moreover, they protect dopamine neurons from oxidative stress, inflammation, and apoptosis, all well-known pathomechanisms of Parkinson's disease (PD). Melatonin is a potent antioxidant that has the beneficial ability to prevent neurodegenerative diseases like PD. We aimed to explore the protective properties of melatonin in an in vitro PD model, focusing on its underlying mechanism u...
Source: Biochemical and Biophysical Research communications - July 10, 2022 Category: Biochemistry Authors: Yu Jin Jung Hyunsu Choi Eungseok Oh Source Type: research
