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Magnesium isoglycyrrhizinate ameliorates radiation-induced pulmonary fibrosis by inhibiting fibroblast differentiation via the p38MAPK/Akt/Nox4 pathway
Publication date: July 2019Source: Biomedicine & Pharmacotherapy, Volume 115Author(s): Qunfang Yang, Pan Zhang, Tao Liu, Xuan Zhang, Xichun Pan, Yanyan Cen, Ya Liu, Haigang Zhang, Xiaohong ChenAbstractRadiation-induced pulmonary fibrosis (RIPF) is a severe complication in patients treated with thoracic irradiation. Until now, there are no effective therapeutic drugs for RIPF. In the present study, we attempted to evaluate the effect of Magnesium isoglycyrrhizinate (MgIG) on RIPF, and to further explore the underlying mechanisms. We found that MgIG treatment markedly improved radiation-induced lung pathological changes, red...
Source: Biomedicine and Pharmacotherapy - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Miao Sui, Xiaofei Jiang, Jun Chen, Haiyan Yang, Yan ZhuAbstractFerroptosis is recently reported as a new mode of regulated cell death. It is triggered by disturbed redox homeostasis, overloaded iron and increased lipid peroxidation. Howerver, the role of ferroptosis in hepatic fibrosis remains obscure. In the current study, we attempted to investigate the effect of Magnesium isoglycyrrhizinate (MgIG) on ferroptosis in liver fibrosis, and to further clarify the possible mechanisms. Our data showed that MgIG treatment markedly attenuate...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research