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Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor < sub > 1/3 < /sub > , Src, and extracellular signal-regulated kinase
Eur J Pharmacol. 2022 Apr 28:174986. doi: 10.1016/j.ejphar.2022.174986. Online ahead of print.ABSTRACTConnexin 43 (Cx43) expression is decreased in the prefrontal cortex of patients with depression, but its significance is still unknown. Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), are involved in the effects of antidepressant. However, the relationship between Cx43 expression and induction of brain-derived neurotrophic factor production by antidepressants is unknown. On the basis of our previous study, which showed that adrenergic receptors stimulation results in potentiation of BDNF expression ...
Source: European Journal of Pharmacology - May 1, 2022 Category: Drugs & Pharmacology Authors: Nozomi Tokunaga Tomoyo Takimoto Yoki Nakamura Kazue Hisaoka-Nakashima Norimitsu Morioka Source Type: research

Antidepressants activate the lysophosphatidic acid receptor LPA1 to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts.
Abstract Different lines of evidence indicate that the lysophosphatidic acid (LPA) receptor LPA1 is involved in neurogenesis, synaptic plasticity and anxiety-related behaviour, but little is known on whether this receptor can be targeted by neuropsychopharmacological agents. The present study investigated the effects of different antidepressants on LPA1 signaling. We found that in Chinese hamster ovary (CHO)-K1 fibroblasts expressing endogenous LPA1 tricyclic and tetracyclic antidepressants and fluoxetine induced the phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2) and CREB. This response was a...
Source: Biochemical Pharmacology - April 15, 2015 Category: Drugs & Pharmacology Authors: Olianas MC, Dedoni S, Onali P Tags: Biochem Pharmacol Source Type: research