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Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment
Drug Deliv. 2022 Dec;29(1):889-905. doi: 10.1080/10717544.2022.2050845.ABSTRACTAs there is currently no effective therapy for patients with prostate cancer (PCa) bone metastasis, it was stringent to explore the relevant treatment strategies. Actually, the interaction between cancer cells and bone microenvironment plays important role in prostate cancer bone metastasis, especially the Sonic hedgehog protein (SHH) signaling in the bone microenvironment. The SHH promotes osteoblast maturation and osteoblast then secretes RANKL to induce osteoclastogenesis. Herein, this study develops bone-targeting calcium phosphate lipid hyb...
Source: Drug Delivery - March 14, 2022 Category: Drugs & Pharmacology Authors: Xiangyu Zhang Qingbin Liu Tingting Zhang Pei Gao Hui Wang Lu Yao Jingwen Huang Shulong Jiang Source Type: research

Abstract 3310: N-cadherin promotes docetaxel resistance through upregulated TLR4 signaling in castration resistant prostate cancers
In this study, our objective is to determine the role of N-cadherin expression in chemoresistance and whether treatment with monoclonal antibodies restores chemosensitivity. Methods: Tissue microarrays of CRPC and high grade prostate cancer clinical samples were stained for TLR4. N-cadherin positive and negative cell lines were evaluated for sensitivity against docetaxel. N-cadherin and TLR4 were ectopically expressed in N-cadherin negative prostate cancer cells (LNCaP, VCaP). Docetaxel resistant cell lines (LNCaP-DocR and VCaP-DocR) were established through prolonged exposure to 10-20uM Docetaxel. For in vitro experiments...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Shimomura, T., Kono, E., Tran, C. P., Yamashiro, J., Lin, S., Lee, S. H.-K., Wainberg, Z. A., Reiter, R. E. Tags: Molecular and Cellular Biology Source Type: research