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Source: Braz J Med Biol Res
Drug: Propofol
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Total 1 results found since Jan 2013.
Propofol inhibits proliferation, migration, and invasion but promotes apoptosis by regulation of Sox4 in endometrial cancer cells.
This study aimed to explore the effects of propofol on EC in vitro and in vivo. Different concentrations of propofol were used to treat Ishikawa cells. Colony number, cell viability, cell cycle, apoptosis, migration, and invasion were analyzed by colony formation, MTT, flow cytometry, and Transwell assays. In addition, the pcDNA3.1-Sox4 and Sox4 siRNA plasmids were transfected into Ishikawa cells to explore the relationship between propofol and Sox4 in EC cell proliferation. Tumor weight in vivo was measured by xenograft tumor model assay. Protein levels of cell cycle-related factors, apoptosis-related factors, matrix meta...
Source: Braz J Med Biol Res - March 1, 2018 Category: Research Authors: Du Q, Liu J, Zhang X, Zhang X, Zhu H, Wei M, Wang S Tags: Braz J Med Biol Res Source Type: research
