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Condition: Multiple Sclerosis
Drug: Aspirin
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Total 1 results found since Jan 2013.
Aspirin Enhances Astrocytic CNTF Signal Transduction
Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor, and the mechanisms by which CNTF expression could be increased in the brain are poorly understood. Acetylsalicylic acid (aspirin) is one of the most widely used analgesics. Interestingly, aspirin increased mRNA and protein expression of CNTF in primary mouse and human astrocytes in a dose- and time-dependent manner. Aspirin induced the activation of protein kinase A (PKA) but not protein kinase C (PKC). H-89, an inhibitor of PKA, abrogated aspirin-induced expression of CNTF. The activation of cAMP-response element-binding protein (CREB), but not NF-κB,...
Source: Journal of Biological Chemistry - June 21, 2013 Category: Chemistry Authors: Modi, K. K., Sendtner, M., Pahan, K. Tags: Neurobiology Source Type: research
