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Aspirin may influence cellular energy status.
Abstract In our previous findings, we have demonstrated that aspirin/acetyl salicylic acid (ASA) might induce sirtuins via aryl hydrocarbon receptor (Ah receptor). Induction effects included an increase in cellular paraoxonase 1 (PON1) activity and apolipoprotein A1 (ApoA1) gene expression. As predicted, ASA and salicylic acid (SA) treatment resulted in generation of H2O2, which is known to be an inducer of mitochondrial gene Sirt4 and other downstream target genes of Sirt1. Our current mass spectroscopic studies further confirm the metabolism of the drugs ASA and SA. Our studies show that HepG2 cells readily conv...
Source: European Journal of Pharmacology - December 31, 2014 Category: Drugs & Pharmacology Authors: Kamble P, Litvinov D, Aluganti Narasimhulu C, Jiang X, Parthasarathy S Tags: Eur J Pharmacol Source Type: research