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Drug: Morphine
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Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the promoter region of mu-opioid receptor (MOR) to regulate its transcriptional activity. How hnRNP K contributes to the analgesic effects of morphine, however, is largely unknown. We provide evidence that morphine increases hnRNP K protein expression via MOR activation in rat primary cortical neurons and HEK-293 cells expressing MORs, without increasing mRNA levels. Using the bicistronic reporter assay, we examined whether morphine-mediated accumulation of hnRNP K resulted from translational control. We identified potential internal ribosome entry site elements ...
Source: Nucleic Acids Research - November 27, 2014 Category: Research Authors: Lee, P.-T., Chao, P.-K., Ou, L.-C., Chuang, J.-Y., Lin, Y.-C., Chen, S.-C., Chang, H.-F., Law, P.-Y., Loh, H. H., Chao, Y.-S., Su, T.-P., Yeh, S.-H. Tags: Gene regulation, Chromatin and Epigenetics Source Type: research
