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Source: IUBMB Life
Drug: Metformin
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Total 2 results found since Jan 2013.
RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial ‐protective effects of metformin under high glucose in HUVECs
AbstractImpaired angiogenesis in endothelial cells is a hallmark of diabetes vascular complications. Ras guanine ‐releasing protein 1 (RasGRP1) is a guanine nucleotide exchange factor for Ras, and its role in endothelial angiogenesis has not been investigated. Given the importance of Ras in vascular endothelial growth factor (VEGF)‐induced angiogenesis, we hypothesized that RasGRP1 may be a critical pathwa y downstream of VEGF and involved in endothelial angiogenesis. Furthermore, we investigate whether RasGRP1‐dependent VEGF signaling was downregulated under high glucose conditions mimicking diabetes and required fo...
Source: IUBMB Life - May 22, 2019 Category: Research Authors: Jing Xu,
Miao Liu,
Muqiao Yu,
Jiayi Shen,
Jiecan Zhou,
Jinglei Hu,
Yong Zhou,
Wei Zhang Tags: Research Communication Source Type: research
