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MicroRNA-296, a suppressor non-coding RNA, downregulates SGLT2 expression in lung cancer.
In this study, we aimed to determine the role of miR‑296‑5p in lung cancer and whether this involves the targeting of SGLT2. For this purpose, we examined miR‑296‑5p and SGLT2 expression in human lung cancer samples and cell lines by RT-qPCR and western blot analysis. In addition, the data analysis website TCGA was used for survival analysis with respect to SGLT2 expression. The effects of miR‑296‑5p were also examined on cell proliferation and cell cycle progression using respective assays. The results demonstrate that miR‑296‑5p is significantly downregulated in NSCLC tissues. Additionally, it is demonstr...
Source: International Journal of Oncology - October 19, 2018 Category: Cancer & Oncology Authors: Zhang X, Zhang X, Liu X, Qi P, Wang H, Ma Z, Chai Y Tags: Int J Oncol Source Type: research