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A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV
The objective of this study was to evaluate available literature on the possible efficacy of second-line treatments in HSV and the use of second-line treatments in HSV strains that are resistant to first-line treatments. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a final search was conducted in six databases on November 5, 2021 for all relevant literature using terms related to antiviral resistance, herpes, and HSV. Eligible manuscripts were required to report the presence of an existing or proposed second-line treatment for HSV-1, HSV-2, or varicella zoster virus (VZV...
Source: Herpes - April 12, 2023 Category: Infectious Diseases Authors: Kimberly C Lince Virgil K DeMario George T Yang Rita T Tran Daniel T Nguyen Jacob N Sanderson Rachel Pittman Rebecca L Sanchez Source Type: research

Host Cell Neddylation Facilitates Alphaherpesvirus Entry in a Virus-Specific and Cell-Dependent Manner
Microbiol Spectr. 2022 Sep 29:e0311422. doi: 10.1128/spectrum.03114-22. Online ahead of print.ABSTRACTHerpes simplex virus 1 (HSV-1) commandeers the host cell proteasome at several steps of its replication cycle, including entry. Here we demonstrate that HSV-2, pseudorabies virus (PRV), and bovine herpesvirus 1 (BoHV-1) entry are blocked by bortezomib, a proteasome inhibitor that is an FDA-approved cancer drug. Proteasome-dependent entry of HSV-1 is thought to be ubiquitin-independent. To interrogate further the proteasomal mechanism of entry, we determined the involvement of the ubiquitin-like molecule NEDD8 and the neddy...
Source: Herpes - September 29, 2022 Category: Infectious Diseases Authors: Becky H Lee Giulia Tebaldi Suzanne M Pritchard Anthony V Nicola Source Type: research