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Specialty: Chemistry
Drug: Gleevec
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AMPK Inhibits Oxidative Stress-induced Caveolin-1 Phosphorylation Cell Biology
Caveolin-1 is the primary structural component of endothelial caveolae that is essential for transcellular trafficking of albumin and is also a critical scaffolding protein that regulates the activity of signaling molecules in caveolae. Phosphorylation of caveolin-1 plays a fundamental role in the mechanism of oxidant-induced vascular hyper permeability. However, the regulatory mechanism of caveolin-1 phosphorylation remains unclear. Here we identify a previously unexpected role for AMPK in inhibition of caveolin-1 phosphorylation under oxidative stress. A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide ...
Source: Journal of Biological Chemistry - July 12, 2013 Category: Chemistry Authors: Takeuchi, K., Morizane, Y., Kamami-Levy, C., Suzuki, J., Kayama, M., Cai, W., Miller, J. W., Vavvas, D. G. Tags: Signal Transduction Source Type: research
