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Condition: Diabetes
Drug: Gleevec
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Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin producing cells
LRP1 is an endocytic and multifunctional type I cell surface membrane protein, which is known to be phosphorylated by the activated PDGF receptor (PDGFR). The tyrosine kinase inhibitor imatinib, which inhibits PDGFR and c-Abl, and which has previously been reported to counteract beta-cell death and diabetes, has been suggested to ameliorate atherosclerosis by inhibiting PDGFR-induced LRP1 phosphorylation. The aim of this investigation was to study LRP1 function in beta-cells and to what extent imatinib modulates LRP1 activity. LRP1 and c-Abl gene knockdown was performed by RNAi using rat INS-1 832/13 and human EndoC1-bH1 c...
Source: Clinical Science - May 28, 2014 Category: Biomedical Science Authors: R Göran Fred, S Kumar Boddeti, M Lundberg, N Welsh Source Type: research
