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TMEM232 Promotes the Inflammatory Response in Atopic Dermatitis via NF- κB and STAT3 Signaling Pathways
CONCLUSION: The study first outlines the function of TMEM232. It is involved in regulating inflammation in AD and may be a potential target for AD treatment.PMID:36928730 | DOI:10.1093/bjd/ljad078
Source: The British Journal of Dermatology - March 17, 2023 Category: Dermatology Authors: Jie Han Xinying Cai Shichun Qin Zengyunou Zhang Yuanyuan Wu Yuanzhe Shi Tingyue Deng Benjin Chen Li Liu Haisheng Qian Wenliang Fang Fengli Xiao Source Type: research

CERKL is Upregulated in Cutaneous Squamous Cell Carcinoma and Maintains Cellular Sphingolipids and Resistance to Oxidative Stress.
CONCLUSIONS: These findings suggest that CERKL may be important in cSCC progression and could lead to novel strategies for prevention and treatment of cSCC. PMID: 33270220 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - December 3, 2020 Category: Dermatology Authors: Meyer JM, Lee E, Celli A, Park K, Cho R, Lambert W, Pitchford M, Gordon M, Tsai K, Cleaver J, Arron ST, Mauro TM Tags: Br J Dermatol Source Type: research

Upregulated E3 ligase Trim21 in psoriatic epidermis ubiquitylates NF- κB p65 subunit and promotes inflammation in keratinocytes.
CONCLUSIONS: Our study confirms that upregulated Trim21 in psoriatic epidermis ubiquitylates p65 and activates the NF-κB pathway, which promotes keratinocyte inflammation. Hence, Trim21 represents a potential target for psoriasis treatment. PMID: 32232831 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - March 29, 2020 Category: Dermatology Authors: Yang L, Zhang T, Zhang C, Xiao C, Bai X, Wang G Tags: Br J Dermatol Source Type: research

Evidence for a "window of opportunity" in hidradenitis suppurativa treated with adalimumab: a retrospective, real-life multicenter cohort study.
CONCLUSION: Inverse correlation between therapeutic delay and clinical response was found, supporting early adalimumab use and providing evidence for a "window of opportunity" in HS. Adalimumab efficacy and safety were confirmed, along with patients' QoL improvement. Immunosuppressants could negatively influence response to adalimumab inducing a switch to non-TNFα -driven pathways. PMID: 32119111 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - March 1, 2020 Category: Dermatology Authors: Marzano AV, Genovese G, Casazza G, Moltrasio C, Dapavo P, Micali G, Sirna R, Gisondi P, Patrizi A, Dini V, Bianchini D, Bianchi L, Fania L, Prignano F, Offidani A, Atzori L, Bettoli V, Cannavò SP, Venturini M, Bongiorno MR, Costanzo A, Fabbrocini G, Peri Tags: Br J Dermatol Source Type: research

A new Th-17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26.
CONCLUSIONS: Our findings suggest that infection susceptibility in HS might be related to IL-26. Despite the role of bacteria remains controversial in HS, this paper supports that there is a defect of antimicrobial response in these patients. This article is protected by copyright. All rights reserved. PMID: 30829398 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - March 3, 2019 Category: Dermatology Authors: Scala E, Di Caprio R, Cacciapuoti S, Caiazzo G, Fusco A, Tortorella E, Fabbrocini G, Balato A Tags: Br J Dermatol Source Type: research

Interleukin-32 promotes detachment and activation of human Langerhans cells in a human skin explant model.
CONCLUSIONS: We propose, for the first time, that IL-32 is a molecular link between KCs and LCs in healthy skin, provoking LC migration from the epidermis to the dermis prior to their migration to the draining lymph nodes. PMID: 29806155 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - May 28, 2018 Category: Dermatology Authors: Gonnet J, Perrin H, Hutton AJ, Boccara D, Bonduelle O, Mimoun M, Atlan M, Soria A, Combadière B Tags: Br J Dermatol Source Type: research

Adipochemokines induced by ultraviolet irradiation contribute to impaired fat metabolism in subcutaneous fat cells.
CONCLUSIONS: These UV-induced adipochemokines may be implicated in the reduction of lipogenesis in SC fat, leading to impairment of fat homeostasis and associated comorbidities such as obesity. This article is protected by copyright. All rights reserved. PMID: 28845522 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - August 27, 2017 Category: Dermatology Authors: Kim EJ, Kim YK, Kim S, Kim JE, Tian YD, Doh EJ, Lee DH, Chung JH Tags: Br J Dermatol Source Type: research