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Fundamental Studies on Development of Next-generation Medium Sized Peptide Drugs
Yakugaku Zasshi. 2022;142(10):1061-1066. doi: 10.1248/yakushi.22-00115.ABSTRACTMedium-sized peptides are expected as a next-generation drug discovery modality because they combine the properties of conventional small-molecule drugs and biopharmaceuticals. Nonetheless, peptides are easily degraded by digestive enzymes such as protease in the body, which could be problematic for the development of peptide-based drugs. To overcome such a problem, peptide-based foldamers containing non-proteinogenic amino acids or cyclized peptides have been reported. In addition, peptides must form stable secondary structures and their side c...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 2, 2022 Category: Drugs & Pharmacology Authors: Takashi Misawa Source Type: research
