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Triggering Receptor Expressed on Myeloid Cell-2 Protects PC12 Cells Injury by Inhibiting BV2 Microglial Activation
Jian-Wu Ni, Cai-Xia Li, Xiong-Wei Chen, Wen-Pin CaiNeurology India 2022 70(6):2378-2382 Microglia play a crucial role in the activation of immune defense mechanism as the resident macrophages in the central nervous system (CNS). Microglia can eliminate damaged neurons, plaques, and other infectious agents. Triggering receptor expressed on myeloid cell-2 (TREM-2) speculates to be beneficial in preventing inflammation-induced bystander damage of neurons. However, the precise molecular mechanisms underlying the regulation of TREM-2 on neurons are not clarified. We cultured PC12 cells with conditioned medium which was the sup...
Source: Neurology India - December 19, 2022 Category: Neurology Authors: Jian-Wu Ni Cai-Xia Li Xiong-Wei Chen Wen-Pin Cai Source Type: research