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Source: Tumor Biology
Condition: Benign Prostatic Hyperplasia
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Total 1 results found since Jan 2013.
Inhibition of LDHA suppresses tumor progression in prostate cancer
Abstract
A key hallmark of cancer cells is their altered metabolism, known as Warburg effect. Lactate dehydrogenase A (LDHA) executes the final step of aerobic glycolysis and has been reported to be involved in the tumor progression. However, the function of LDHA in prostate cancer has not been studied. In current study, we observed overexpression of LDHA in the clinical prostate cancer samples compared with benign prostate hyperplasia tissues as demonstrated by immunohistochemistry and real-time qPCR. Attenuated expression of LDHA by siRNA or inhibition of LDHA activities by FX11 inhibited cell proliferation, mig...
Source: Tumor Biology - May 16, 2015 Category: Cancer & Oncology Source Type: research
