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Aldosterone and Store-operated Ca2+ Channels Cell Biology
Store-operated Ca2+ entry (SOCE) has emerged as an important mechanism in cardiac pathology. However, the signals that up-regulate SOCE in the heart remain unexplored. Clinical trials have emphasized the beneficial role of mineralocorticoid receptor (MR) signaling blockade in heart failure and associated arrhythmias. Accumulated evidence suggests that the mineralocorticoid hormone aldosterone, through activation of its receptor, MR, might be a key regulator of Ca2+ influx in cardiomyocytes. We thus assessed whether and how SOCE involving transient receptor potential canonical (TRPC) and Orai1 channels are regulated by aldo...
Source: Journal of Biological Chemistry - June 16, 2016 Category: Chemistry Authors: Sabourin, J., Bartoli, F., Antigny, F., Gomez, A. M., Benitah, J.-P. Tags: Cell Biology Source Type: research