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Specialty: Chemistry
Condition: Thrombosis
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The heterotrimeric G protein G{beta}1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets Cell Biology
Thrombosis is caused by the activation of platelets at the site of ruptured atherosclerotic plaques. This activation involves engagement of G protein–coupled receptors (GPCR) on platelets that promote their aggregation. Although it is known that protein kinases and phosphatases modulate GPCR signaling, how serine/threonine phosphatases integrate with G protein signaling pathways is less understood. Because the subcellular localization and substrate specificity of the catalytic subunit of protein phosphatase 1 (PP1c) is dictated by PP1c-interacting proteins, here we sought to identify new PP1c interactors. GPCRs signal vi...
Source: Journal of Biological Chemistry - August 11, 2017 Category: Chemistry Authors: Subhashree Pradhan, Tanvir Khatlani, Angus C. Nairn, K. Vinod Vijayan Tags: Signal Transduction Source Type: research
