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Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro
AbstractIntracerebral hemorrhage is the most dangerous complication in tPA thrombolytic therapy for ischemic stroke, which occurs as a consequence of endothelial cell death at the blood brain barrier (BBB) during thrombolytic reperfusion. We have previously shown that cerebral ischemia induced rapid occludin degradation and BBB disruption. Here we demonstrated an important role of occludin degradation in facilitating the evolution of ischemic endothelial cells towards death. Cultured brain microvascular endothelial cells (bEnd.3 cells) were exposed to oxygen ‐glucose deprivation (OGD) or incubated with occludin siRNA or ...
Source: Journal of Neurochemistry - June 11, 2020 Category: Neuroscience Authors: Yuan Zhang, Xiaofeng Li, Shanshan Qiao, Dexin Yang, Zongyang Li, Ji Xu, Weiping Li, Li Su, Wenlan Liu Tags: ORIGINAL ARTICLE Source Type: research

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 20, 2013 Category: Neurology Authors: Ying‐Na Li, Rong Pan, Xu‐Jun Qin, Wei‐Lin Yang, Zhifeng Qi, Wenlan Liu, Ke Jian Liu Tags: Original Article Source Type: research