• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Retrotransposon activation contributes to neurodegeneration in a < i > Drosophila < /i > TDP-43 model of ALS
We report that such expression of hTDP-43 impairs small interfering RNA (siRNA) silencing, which is the major post-transcriptional mechanism of retrotransposable element (RTE) control in somatic tissue. This is accompanied by de-repression of a panel of both LINE and LTR families of RTEs, with somewhat different elements being active in response to hTDP-43 expression in glia versus neurons. hTDP-43 expression in glia causes an early and severe loss of control of a specific RTE, the endogenous retrovirus (ERV)gypsy. We demonstrate thatgypsy causes the degenerative phenotypes in these flies because we are able to rescue the ...
Source: PLoS Genetics - March 15, 2017 Category: Genetics & Stem Cells Authors: Lisa Krug Source Type: research