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Source: British Journal of Pharmacology
Condition: ALS
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δ‐Opioid Receptors Up‐regulate Excitatory Amino Acid Transporters in Mouse Astrocytes
Conclusions and ImplicationsDOR activation upregulates astrocytic EAATs via MEK‐ERK‐p38 signaling, suggesting a critical role of DOR in the regulation of astrocytic EAATs and neuroprotection against excitotoxic injury. Since decreased EAAT expression contributes to pathophysiology in many neurological diseases such as amyotrophic lateral sclerosis, our findings present a new platform for potential treatments of these diseases.
Source: British Journal of Pharmacology - July 23, 2014 Category: Drugs & Pharmacology Authors: Jianfeng Liang, Dongman Chao, Harleen K Sandhu, Yanbing Yu, Li Zhang, Gianfranco Balboni, Dong H Kim, Ying Xia Tags: Research Paper Source Type: research
