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Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in  vitro and in vivo study
In conclusion, our study demonstrates that GAB2 is a potential therapeutic target for OA.PMID:36007472 | DOI:10.1016/j.bbrc.2022.08.006
Source: Biochemical and Biophysical Research communications - August 25, 2022 Category: Biochemistry Authors: Haokun Mo Siying Yang An-Min Chen Source Type: research

Identification of lncRNA and mRNA expression profiles in dorsal root ganglion in rats with cancer-induced bone pain
CONCLUSION: LncRNA played important roles in regulation of CIBP or mRNA expression in peripheral neuropathy in CIBP. These alterd mRNAs and lncRNAs might be potential therapeutic targets for the treatment of CIBP.PMID:34364296 | DOI:10.1016/j.bbrc.2021.07.063
Source: Biochemical and Biophysical Research communications - August 7, 2021 Category: Biochemistry Authors: Jinrong Wei Qianshu Dou Futing Ba Guang-Yin Xu Guo-Qin Jiang Source Type: research

Secreted PLA < sub > 2 < /sub > -III is a possible therapeutic target to treat neuropathic pain
Biochem Biophys Res Commun. 2021 Jul 5;568:167-173. doi: 10.1016/j.bbrc.2021.06.058. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) plays a critical role in developing and maintaining chronic pain in various animal models. Previous studies have reported that cytosolic and calcium-independent phospholipase A2 (PLA2) is involved in the LPA receptor-mediated amplification of LPA production in the spinal dorsal horn (SDH) after nerve injury, while the involvement of secreted PLA2 (sPLA2) remains unclear. The present study revealed that only sPLA2 -III among 11 species of PLA2 showed a significant upregulation of gen...
Source: Biochemical and Biophysical Research communications - July 8, 2021 Category: Biochemistry Authors: Keigo Tanaka Naoki Dozono Hiroyuki Neyama Jun Nagai Ryoko Tsukahara Kazuki Nagayasu Shuji Kaneko Hiroshi Ueda Source Type: research

Upregulation of lncRNA-NONRATT021203.2 in the dorsal root ganglion contributes to cancer-induced pain via CXCL9 in rats.
In this study, we found that lncRNA-NONRATT021203.2 was increased in the CIP rats and that lncRNA-NONRATT021203.2-siRNA could relieve hyperalgesia in these rats. For elucidation of the underlying mechanism, we showed that lncRNA-NONRATT021203.2 could target C-X-C motif chemokine ligand 9 (CXCL9), which was increased in the CIP rats, and that CXCL9-siRNA could relieve hyperalgesia. At the same time, silencing lncRNA-NONRATT021203.2 expression decreased the mRNA and protein levels of CXCL9. Immunofluorescence analysis showed that CXCL9 was mainly expressed in the CGRP-positive and IB4-positive DRG neurons. Further research s...
Source: Biochemical and Biophysical Research communications - February 11, 2020 Category: Biochemistry Authors: Sun RM, Wei J, Wang SS, Xu GY, Jiang GQ Tags: Biochem Biophys Res Commun Source Type: research

The short interference RNA (siRNA) targeting NMUR2 relieves nociception in a bone cancer pain model of rat through PKC-ERK and PI3K-AKT pathways.
CONCLUSION: si-NMUR2 alleviates BCP via inactivation of PKC/ERK and PI3K/AKT signal pathways. PMID: 30914203 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - March 22, 2019 Category: Biochemistry Authors: Peng S, Lu Y, Li P, Liu P, Shi X, Liu C, Zhang Y, Liu S, Wang J Tags: Biochem Biophys Res Commun Source Type: research