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Rab27a-mediated exosome secretion in anterior cingulate cortex contributes to colorectal visceral pain in adult mice with neonatal maternal deprivation
CONCLUSIONS: This study suggested that overexpression of Rab27a increased exosome secretion in ACC neurons, thus contributing to visceral hyperalgesia in NMD mice.PMID:37529842 | DOI:10.1152/ajpgi.00029.2023
Source: Am J Physiol Gastroi... - August 2, 2023 Category: Gastroenterology Authors: Qian Sun Rui-Xia Weng Jia-Hui Li Yong-Chang Li Ji-Tian Xu Rui Li Xiaomin Lu Guang-Yin Xu Source Type: research

PAR-2 activation enhances weak acid-induced ATP release through TRPV1 and ASICs sensitization in human esophageal epithelial cells.
Abstract Esophageal visceral hypersensitivity has been proposed to be the pathogenesis of heartburn sensation in non-erosive reflux disease. Protease-activated receptor-2 (PAR-2) is expressed in human esophageal epithelial cells, and is believed to play a role in inflammation and sensation. PAR-2 activation may modulate these responses through adenosine triphosphate (ATP) release, which is involved in transduction of sensation and pain. The transient receptor potential vanilloid receptor 1 (TRPV1) and acid-sensing ion channels (ASICs) are both acid-sensitive nociceptors. However, the interaction among these molecu...
Source: Am J Physiol Gastroi... - August 20, 2015 Category: Gastroenterology Authors: Wu L, Oshima T, Shan J, Sei H, Tomita T, Ohda Y, Fukui H, Watari J, Miwa H Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research