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Metformin reverses oxidative stress ‑induced mitochondrial dysfunction in pre‑osteoblasts via the EGFR/GSK‑3β/calcium pathway
Int J Mol Med. 2023 Apr;51(4):36. doi: 10.3892/ijmm.2023.5239. Epub 2023 Mar 31.ABSTRACTOxidative stress is one of the main causes of osteoblast apoptosis induced by post‑menopausal osteoporosis. The authors previously found that metformin can reverse the loss of bone mass in post‑menopausal osteoporosis. The present study aimed to further clarify the effects and mechanisms of action of metformin in post‑menopausal osteoporosis under conditions of oxidative stress. Combined with an in‑depth investigation using the transcriptome database, the association between oxidative stress and mitochondrial dysfunction in post...
Source: Molecular Medicine - March 31, 2023 Category: Molecular Biology Authors: Fangming Cao Keda Yang Shui Qiu Jie Li Wen Jiang Lin Tao Yue Zhu Source Type: research

MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2
Exp Mol Med. 2022 Jul 13. doi: 10.1038/s12276-022-00799-9. Online ahead of print.ABSTRACTMicroRNAs (miRNAs) broadly regulate normal biological functions of bone and the progression of fracture healing and osteoporosis. Recently, it has been reported that miR-1224-5p in fracture plasma is a potential therapy for osteogenesis. To investigate the roles of miR-1224-5p and the Rap1 signaling pathway in fracture healing and osteoporosis development and progression, we used BMMs, BMSCs, and skull osteoblast precursor cells for in vitro osteogenesis and osteoclastogenesis studies. Osteoblastogenesis and osteoclastogenesis were det...
Source: Molecular Medicine - July 13, 2022 Category: Molecular Biology Authors: Liangcong Hu Xudong Xie Hang Xue Tiantian Wang Adriana C Panayi Ze Lin Yuan Xiong Faqi Cao Chengcheng Yan Lang Chen Peng Cheng Kangkang Zha Yun Sun Guodong Liu Chenyan Yu Yiqiang Hu Ranyang Tao Wu Zhou Bobin Mi Guohui Liu Source Type: research

Harmine targets inhibitor of DNA binding-2 and activator protein-1 to promote preosteoclast PDGF-BB production
In conclusion, our data demonstrated a novel mechanism involving in the production of PDGF-BB increased by harmine, which may provide potential therapeutic targets for bone loss diseases.PMID:33960660 | DOI:10.1111/jcmm.16562
Source: Molecular Medicine - May 7, 2021 Category: Molecular Biology Authors: Jie Huang You-You Li Kun Xia Yi-Yi Wang Chun-Yuan Chen Meng-Lu Chen Jia Cao Zheng-Zhao Liu Zhen-Xing Wang Hao Yin Xiong-Ke Hu Zheng-Guang Wang Yong Zhou Hui Xie Source Type: research