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Mouse Bone Marrow Sca-1+ CD44+ Mesenchymal Stem Cells Kill Avirulent Mycobacteria but Not Mycobacterium tuberculosis through Modulation of Cathelicidin Expression via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Mycobacterium tuberculosis primarily infects lung macrophages. However, a recent study showed that M. tuberculosis also infects and persists in a dormant form inside bone marrow mesenchymal stem cells (BM-MSCs) even after successful antibiotic therapy. However, the mechanism(s) by which M. tuberculosis survives in BM-MSCs is still not known. Like macrophages, BM-MSCs do not contain a well-defined endocytic pathway, which is known to play a central role in the clearance of internalized mycobacteria. Here, we studied the fate of virulent and avirulent mycobacteria in Sca-1+ CD44+ BM-MSCs. We found that BM-MSCs were able to k...
Source: Infection and Immunity - September 20, 2017 Category: Infectious Diseases Authors: Naik, S. K., Padhi, A., Ganguli, G., Sengupta, S., Pati, S., Das, D., Sonawane, A. Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research