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GADD34 activates p53 and may have utility as a marker of atherosclerosis
Front Med (Lausanne). 2023 May 9;10:1128921. doi: 10.3389/fmed.2023.1128921. eCollection 2023.ABSTRACTWe previously identified growth arrest and DNA-damage-inducible gene 34 (GADD34) as a marker of ischemic stroke. In the present study, serum levels of anti-GADD34 antibodies were found to be significantly higher in patients with acute ischemic stroke or chronic kidney disease compared to healthy donors. We then examined the biological function of GADD34 by transfection into U2OS human osteosarcoma and U87 human glioblastoma cells. Knockdown of GADD34 by siRNA resulted in enhanced cell proliferation, which was reversed by c...
Source: Atherosclerosis - May 25, 2023 Category: Cardiology Authors: Go Tomiyoshi Rika Nakamura Natsuko Shinmen Yoichi Yoshida Seiichiro Mine Toshio Machida Katsuro Iwase Yasuo Iwadate Takaki Hiwasa Hideyuki Kuroda Source Type: research

DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction
Eur J Pharm Sci. 2022 Mar 5:106164. doi: 10.1016/j.ejps.2022.106164. Online ahead of print.ABSTRACTAtherosclerosis is the common pathophysiological foundation of ischaemic stroke and myocardial ischaemia. Oxidative stress is intricately related to the progress of atherosclerosis. DL-3-n-butylphthalide (NBP) is a synthesized raceme of L-3-n-butylphthalide that is first isolated from celery. As a neuroprotective agent, NBP also exhibits potent antioxidative activity. Our research aimed to evaluate the effect of NBP on atherosclerosis and to explore the underlying antioxidative mechanisms and targets. Firstly, we detected the...
Source: Atherosclerosis - March 8, 2022 Category: Cardiology Authors: Jibo Han Xiaowen Shi Jiajun Xu Wante Lin Yanghao Chen Bingjiang Han Yi Wang Jianjiang Xu Source Type: research