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Isoflurane and Netrin-1 combination therapy enhances angiogenesis and neurological recovery by improving the expression of HIF-1 α-Netrin-1-UNC5B/VEGF cascade to attenuate cerebral ischemia injury
In conclusion, our results suggested that ISO combined with NT-1 could promote angiogenesis, recover long-term neurobehavioral function, and attenuate cerebral ischemia injury by activating the HIF-1α-Netrin-1-UNC5B/VEGF cascade.PMID:35247371 | DOI:10.1016/j.expneurol.2022.114028
Source: Experimental Neurology - March 5, 2022 Category: Neurology Authors: Nian Li Xu Zhang Jingwen Zhai Jiangwen Yin Ketao Ma Ruixue Wang Xinlei Qin Yan Li Xiwei Dong Sheng Wang Source Type: research

Delayed recanalization after MCAO ameliorates ischemic stroke by inhibiting apoptosis via HGF/c-met/STAT3/Bcl-2 pathway in rats.
In conclusion, the delayed recanalization after MCAO increased the expression of HGF in the brain, and reduced the infarction and neuronal apoptosis after MCAO, partly via the activation of the HGF/c-Met/STAT3/Bcl-2 signaling pathway. The delayed recanalization may serve as a therapeutic alternative for a subset of ischemic stroke patients. PMID: 32428505 [PubMed - as supplied by publisher]
Source: Experimental Neurology - May 15, 2020 Category: Neurology Authors: Tang H, Gamdzyk M, Huang L, Gao L, Lenahan C, Kang R, Tang J, Xia Y, Zhang JH Tags: Exp Neurol Source Type: research

MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression.
CONCLUSION: MiR-193b-3p has a potentially neuroprotective effect on focal cerebral I/R-induced injury by inhibiting 5-LOX expression. PMID: 32032565 [PubMed - as supplied by publisher]
Source: Experimental Neurology - February 3, 2020 Category: Neurology Authors: Chen Z, Yang J, Zhong J, Luo Y, Du W, Hu C, Xia H, Li Y, Zhang J, Li M, Yang Y, Huang H, Peng Z, Tan X, Wang H Tags: Exp Neurol Source Type: research

Deletion of Chitinase-3-like 1 accelerates stroke development through enhancement of Neuroinflammation by STAT6-dependent M2 microglial inactivation in Chitinase-3-like 1 knockout mice.
Abstract Chitinase 3-like 1 (Chi3L1) plays a major role in the pathogenesis of inflammatory diseases. We investigated the effect of Chi3L1 knockout on stroke development. Ischemia/reperfusion was induced by middle cerebral artery occlusion (MCAO) in Chi3L1 knockout and wildtype mice. Significantly increased infarct volume and decreased neurological deficit scores at 24 h after ischemia/reperfusion were found in Chi3L1 knockout mice compared to wildtype mice. Moreover, ischemic neuronal cell death was increased in Chi3L1 knockout mice through increased oxidative stress and release of IL-6 and IL-1β but IL-10 and...
Source: Experimental Neurology - October 23, 2019 Category: Neurology Authors: Im JH, Yeo IJ, Park PH, Choi DY, Han SB, Yun J, Hong JT Tags: Exp Neurol Source Type: research

Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats.
Abstract Reperfusion exceeded time window may induce ischemia/reperfusion injury, increase hemorrhagic transformation, and deteriorate neurological outcomes in ischemic stroke models. However, the increasing clinical evidences supported that reperfusion even within 6-24 h may salvage ischemic tissue and improve neurological outcomes in selected large vessel occlusion patients, without inducing serious ischemia/reperfusion injury and hemorrhagic transformation. The underlying molecular mechanisms are less clear. In present study, we demonstrated that delayed recanalization at 3 days after permanent middle cereb...
Source: Experimental Neurology - July 7, 2019 Category: Neurology Authors: Zheng W, Matei N, Pang J, Luo X, Song Z, Tang J, Zhang JH Tags: Exp Neurol Source Type: research

TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats.
CONCLUSIONS: TDAG8 plays an important neuroprotective role through inhibition of neuronal apoptosis and alleviation of neurological deficits by activating the Akt signalling pathway in rats. PMID: 28365474 [PubMed - as supplied by publisher]
Source: Experimental Neurology - March 29, 2017 Category: Neurology Authors: Ma XD, Hang LH, Shao DH, Shu WW, Hu XL, Luo H Tags: Exp Neurol Source Type: research