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Gene therapy in the anterior eye segment
Curr Gene Ther. 2021 Apr 22. doi: 10.2174/1566523221666210423084233. Online ahead of print.ABSTRACTThis review provides comprehensive information about the advances in gene therapy in the anterior segment of the eye including cornea, conjunctiva, lacrimal gland, and trabecular meshwork. We discuss gene delivery systems including viral and non-viral vectors as well as gene editing techniques, mainly CRISPR-Cas9, and epigenetic treatments including antisense and siRNA therapeutics. We also provide a detailed analysis of various anterior segment diseases where gene therapy has been tested with corresponding outcomes. Disease ...
Source: Current Gene Therapy - April 27, 2021 Category: Genetics & Stem Cells Authors: Cynthia Amador Ruchi Shah Sean Ghiam Andrei A Kramerov Alexander V Ljubimov Source Type: research