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Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress
This study investigated the effects of VAL on lipid accumulation and lipogenesis in human primary hepatocytes. Treatment with VAL suppressed lipid accumulation and expressions of lipogenic genes, such as processed sterol regulatory element binding proteins (SREBP1) and stearoyl-CoA desaturase-1 (SCD1) in palmitate-treated hepatocytes. Furthermore, VAL ameliorated dose-dependently palmitate-induced ER stress markers. Treatment of hepatocytes with VAL increased AMPK phosphorylation and SIRT6 expression. siRNA-mediated suppression of AMPK or SIRT6 abolished the effects of VAL on lipid accumulation, lipogenesis, and endoplasmi...
Source: Biochemical Pharmacology - March 31, 2022 Category: Drugs & Pharmacology Authors: Seung Yeon Park Wonjun Cho A M Abd El-Aty Ahmet Hacimuftuoglu Ji Hoon Jeong Tae Woo Jung Source Type: research

Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.
CONCLUSION AND IMPLICATIONS: Our study suggested that the anti-arthritis effects of CTS were attained through suppression of p300-mediated STAT3 acetylation. Our data suggest that CTS might be a potential immune modulator for RA treatment. PMID: 28522406 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - May 15, 2017 Category: Drugs & Pharmacology Authors: Wang Y, Zhou C, Gao H, Li C, Li D, Liu P, Huang M, Shen X, Liu L Tags: Biochem Pharmacol Source Type: research

Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF- κB in human rheumatoid arthritis synovial fibroblasts.
Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-κB in human rheumatoid arthritis synovial fibroblasts. Biochem Pharmacol. 2017 Mar 10;: Authors: Yang CM, Chen YW, Chi PL, Lin CC, Hsiao LD Abstract Bradykinin (BK) induces inflammation in rheumatoid arthritis (RA). Resveratrol is a potent activator of Sirt1 which could modulate inflammation through deacetylating histones of transcription factors. Here, we investigated the mechanisms underlying BK-induced COX-2 expression which is modulated by resveratrol/Sirt1 in human rheumatoid arthritis synovial fibrobla...
Source: Biochemical Pharmacology - March 9, 2017 Category: Drugs & Pharmacology Authors: Yang CM, Chen YW, Chi PL, Lin CC, Hsiao LD Tags: Biochem Pharmacol Source Type: research