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IKK epsilon is key to induction of insulin resistance in the hypothalamus and its inhibition reverses obesity.
Abstract IKK epsilon (IKKε) is induced by the activation of NFκB. Whole body IKKε knockout mice on a high fat diet (HFD) were protected from insulin resistance and showed altered energy balance. Here, we demonstrate that IKKε is expressed in neurons and is upregulated in the hypothalamus of obese mice, contributing to insulin and leptin resistance. Blocking IKKε in the hypothalamus of obese mice, using CAYMAN10576 or siRNA, decreased NFκB activation in this tissue, relieving the inflammatory environment. Inhibition of IKKε activity, but not TBK1, reduced IRS-1(Ser) phosphorylation and insulin and leptin res...
Source: Diabetes - May 8, 2014 Category: Endocrinology Authors: Weissmann L, Quaresma PG, Santos AC, de Matos AH, D'Ávila Bittencourt Pascoal V, Zanotto TM, Castro G, Guadgnini D, Martins da Silva J, Velloso LA, Bittencourt JC, Lopes-Cendes I, Saad MJ, Prada PO Tags: Diabetes Source Type: research

Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - May 1, 2014 Category: Research Authors: Bruno G. Teodoro, Flavia G. Baraldi, Igor H. Sampaio, Lucas H. M. Bomfim, André L. Queiroz, Madla A. Passos, Everardo M. Carneiro, Luciane C. Alberici, Ramon Gomis, Fernanda G. Amaral, José Cipolla‐Neto, Michel B Araújo, Tanes Lima, Sérgio Akira Uye Tags: Original Article Source Type: research