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Condition: Autoimmune Disease
Drug: Paroxetine
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GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3K{gamma}/PREX1 signaling and T cell cytokine secretion Signal Transduction
The immune system includes abundant examples of biologically-relevant cross-regulation of signaling pathways by the T cell antigen receptor (TCR) and the G protein–coupled chemokine receptor, CXCR4. TCR ligation induces transactivation of CXCR4 and TCR–CXCR4 complex formation, permitting the TCR to signal via CXCR4 to activate a phosphatidylinositol 3,4,5-trisphosphate–dependent Rac exchanger 1 protein (PREX1)–dependent signaling pathway that drives robust cytokine secretion by T cells. To understand this receptor heterodimer and its regulation, we characterized the molecular mechanisms required for TCR-mediated TC...
Source: Journal of Biological Chemistry - September 7, 2018 Category: Chemistry Authors: Brittney A. Dinkel, Kimberly N. Kremer, Meagan R. Rollins, Michael J. Medlyn, Karen E. Hedin Tags: Immunology Source Type: research
