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Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease
CONCLUSIONS: TLR4 could exacerbate tubular injury and fibrosis via GSDMD-mediated canonical pyroptosis pathway in T2DKD. Activation of GSDMD could inhibit apoptosis and activate pyroptosis, which may involve the potential switch mechanism between TLR4-mediated pyroptosis and apoptosis in T2DKD.PMID:35809639 | DOI:10.1016/j.abb.2022.109347
Source: Archives of Biochemistry and Biophysics - July 9, 2022 Category: Biochemistry Authors: Shuguang Yuan Youliang Wang Zheng Li Xiaojun Chen Panai Song Anqun Chen Zhong Qu Si Wen Hong Liu Xuejing Zhu Source Type: research

Therapeutic effect and mechanism of combined use of FGF21 and insulin on diabetic nephropathy
In conclusion, our results demonstrate that combination FGF21 with Insulin exhibits a better therapeutic effect on DN compared with FGF21 or Insulin alone. This study provides a theoretical basis for combined used of FGF21 and Insulin as a new treatment for DN and further provides theoretical support for application of FGF21 in treatment of DN.PMID:34695409 | DOI:10.1016/j.abb.2021.109063
Source: Archives of Biochemistry and Biophysics - October 25, 2021 Category: Biochemistry Authors: Fanrui Meng Yukai Cao Mir Hassan Khoso Kai Kang Guiping Ren Wei Xiao Deshan Li Source Type: research

Dulaglutide inhibits high glucose- induced endothelial dysfunction and NLRP3 inflammasome activation.
Abstract Activation of the NLRP3 inflammasome plays an important role in high glucose- induced endothelial dysfunction in patients with type 2 diabetes mellitus (T2DM). Dulaglutide, a newly developed glucagon-like peptide-1 receptor (GLP-1R) agonist, has been approved for the management of T2DM. In the current study, we aimed to investigate whether dulaglutide possesses a protective effect against high glucose- induced activation of the NLRP3 inflammasome. Our results indicate that dulaglutide treatment prevented high glucose- induced generation of reactive oxygen species (ROS) and protein carbonyl, as well as the...
Source: Archives of Biochemistry and Biophysics - July 10, 2019 Category: Biochemistry Authors: Luo X, Hu Y, He S, Ye Q, Lv Z, Liu J, Chen X Tags: Arch Biochem Biophys Source Type: research