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Cystathionine-{gamma}-lyase Activity in Type 1 Diabetes Molecular Bases of Disease
This study investigated the activities of cystathionine-γ-lyase (CSE, the enzyme that catalyzes H2S formation) in livers of type 1 diabetic (T1D) animals and in peripheral blood mononuclear cells (PBMC) isolated from T1D patients. T1D is associated with both hyperketonemia (acetoacetate and β-hydroxybutyrate) and hyperglycemia. This study also examined the role of hyperglycemia and hyperketonemia per se in decreased CSE activity using U937 monocytes and PBMC isolated from healthy subjects. Livers from streptozotocin-treated T1D rats demonstrated a significantly higher reactive oxygen species production, lower CSE protein...
Source: Journal of Biological Chemistry - April 25, 2014 Category: Chemistry Authors: Manna, P., Gungor, N., McVie, R., Jain, S. K. Tags: Metabolism Source Type: research