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mGlu7 VFTD-directed Antagonist Relieves Fear and Stress Signal Transduction
The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. mGlu7 function has been linked to autism, drug abuse, anxiety, and depression. Despite this, it has been difficult to develop specific blockers of native mGlu7 signaling in relevant brain areas such as amygdala and limbic cortex. Here, we present the mGlu7-selective antagonist 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one (XAP044), which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm. There was no effect of XAP...
Source: Journal of Biological Chemistry - April 17, 2014 Category: Chemistry Authors: Gee, C. E., Peterlik, D., Neuhauser, C., Bouhelal, R., Kaupmann, K., Laue, G., Uschold–Schmidt, N., Feuerbach, D., Zimmermann, K., Ofner, S., Cryan, J. F., van der Putten, H., Fendt, M., Vranesic, I., Glatthar, R., Flor, P. J. Tags: Neurobiology Source Type: research